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AICAR
Price range: 48 CAD through 80 CAD
Products Details
Product Description
– AICAR (Acadesine) is an AMPK activator that causes ZMP accumulation, thereby mimicking the stimulatory effect of AMP on both AMPK and AMPKK. It is commonly used in research related to diabetes, cardiovascular diseases, and tumors.
Web ID
– T1477
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C9H14N4O5
Citations
– 1. Rao X S, Cong X X, Gao X K, et al. AMPK-mediated phosphorylation enhances the auto-inhibition of TBC1D17 to promote Rab5-dependent glucose uptake. Cell Death & Differentiation. 2021: 1-21.
2. Qiu W Q, Ai W, Zhu F D, et al. Polygala saponins inhibit NLRP3 inflammasome-mediated neuroinflammation via SHP-2-Mediated mitophagy. Free Radical Biology and Medicine. 2022, 179: 76-94.
3. Fan C, Feng J, Tang C, et al. Melatonin suppresses ER stress-dependent proapoptotic effects via AMPK in bone mesenchymal stem cells during mitochondrial oxidative damage. Stem Cell Research & Therapy. 2020, 11(1): 1-22
4. Liang X, Liang J, Zhang S, et al.Di-2-ethylhexyl phthalate disrupts hepatic lipid metabolism in obese mice by activating the LXR/SREBP-1c and PPAR-α signaling pathways.Science of The Total Environment.2024: 169919.
References
– Corton JM, et al. Eur J Biochem, 1995, 229(2), 558-565.
CAS Number
– 2627-69-2
Molecular Weight
– C9H14N4O5
Compound Purity
– 0.9987
SMILES
– NC(=O)c1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1N
Target
– HDAC
Pathway
– Autophagy|||PI3K/Akt/mTOR signaling|||Chromatin/Epigenetic|||Stem Cells
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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