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Begacestat
142 CAD
Only 1000 item(s) left in stock.
Products Details
Product Description
– Begacestat (GSI-953) is a potent and selective gamma-secretase inhibitor (γ-secretase) that inhibits Amyloid-beta production with nanomolar potency, selectively inhibits cleavage of APP in cellular level Notch cleavage assays, reverses situational memory deficits, and can be used to study Alzheimer’s disease.
Web ID
– T14525
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C9H8ClF6NO3S2
References
– Mayer SC, et al. Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer’s disease. J Med Chem. 2008 Dec 11;51(23):7348-51.
CAS Number
– 769169-27-9
Molecular Weight
– C9H8ClF6NO3S2
SMILES
– C([C@H](NS(=O)(=O)C=1SC(Cl)=CC1)CO)(C(F)(F)F)C(F)(F)F
Target
– Others
Pathway
– Stem Cells|||Proteases/Proteasome|||Neuroscience
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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