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Deruxtecan
$460 – $1,840
Products Details
Product Description
– Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a
maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.
Web ID
– HY-13631E
Storage Temperature
– -20°C (Powder, protect from light, stored under nitrogen)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C52H56FN9O13
References
– [1]NOGUCHI, Shigeru, et al. METHOD FOR SELECTIVELY MANUFACTURING ANTIBODY-DRUG CONJUGATE. WO2017002776A1.|[2]Ogitani Y, et al. Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity. Cancer Sci. 2016 Jul;107(7):1039-46.
CAS Number
– 1599440-13-7
Molecular Weight
– 1034.05
Compound Purity
– 99.94
SMILES
– O=C(C=CC1=O)N1CCCCCC(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(NCOCC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C48)=O)=O)=O)=O)=O)=O
Clinical Information
– Phase 4
Research Area
– Cancer
Solubility
– DMSO : 35 mg/mL (ultrasonic)
Target
– Drug-Linker Conjugates for ADC
Isoform
– Camptothecins
Pathway
– Antibody-drug Conjugate/ADC Related
Product type
– ADC Related
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
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