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Products Details
Product Description
– RIP2 Kinase Inhibitor 4 is a potent and selective RIPK2 PROTAC. RIP2 Kinase Inhibitor 4 effectively degrades RIPK2 (pIC50 of 8) and inhibits the release of related TNF-α[1].
Web ID
– HY-136010
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C50H66F2N14O7S
References
– [1]Afjal H Miah, et al. Optimization of a Series of RIPK2 PROTACs. J Med Chem. 2021 Sep 9;64(17):12978-13003.
CAS Number
– 2126803-41-4
Molecular Weight
– 1045.21
SMILES
– CC1=C(C)NN=C1NC2=NC=NC3=C2C=C(S(C(C)(C)C)(=O)=O)C(OCCCN4CCN(C5=NC=C(C(N[C@@H]6CN(C([C@H](C(C)(C)C)NC([C@H](C)NC)=O)=O)[C@H](C(NC(C(F)=CC=C7)=C7F)=O)C6)=O)N=C5)CC4)=C3
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– PROTACs;RIP kinase
Isoform
– cIAP1;RIPK2
Pathway
– Apoptosis;PROTAC
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
