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SIAIS178
Price range: 266 CAD through 3,648 CAD
Products Details
Product Description
– SIAIS178, a potent and selective degrader of BCR-ABL based on PROTAC technology, exhibits an IC50 of 24 nM.
Web ID
– T12907
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C50H62ClN11O6S2
References
– Zhao Q, et al. Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J Med Chem. 2019 Oct 24;62(20):9281-9298.
CAS Number
– 2376047-73-1
Molecular Weight
– C50H62ClN11O6S2
SMILES
– Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCC(=O)N2CCN(CC2)c2cc(Nc3ncc(s3)C(=O)Nc3c(C)cccc3Cl)nc(C)n2)C(C)(C)C)cc1
Target
– CaMK
Pathway
– Tyrosine Kinase/Adaptors|||Cytoskeletal Signaling|||Angiogenesis|||PROTAC
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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