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Products Details
Product Description
– MC-Sq-Cit-PAB-Gefitinib is a agent-linker conjugate for ADC with potent antitumor activity by using Gefitinib (an EGFR tyrosine kinase inhibitor), linked via the ADC linker MC-Sq-Cit-PAB.
Web ID
– HY-128893
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C50H61ClFN10O9
References
– [1]FLYGARE, John A, et al. Quaternary amine compounds and antibody-drug conjugates thereof. WO2016090050A1.|[2]Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119.
CAS Number
– 1941168-63-3
Molecular Weight
– 1000.53
SMILES
– COC1=CC2=[N+](CC3=CC=C(NC([C@@H](NC(C4(C(NCCCCCN5C(C=CC5=O)=O)=O)CCC4)=O)CCCNC(N)=O)=O)C=C3)C=NC(NC6=CC=C(F)C(Cl)=C6)=C2C=C1OCCCN7CCOCC7
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Drug-Linker Conjugates for ADC
Isoform
– Traditional Cytotoxic Agents
Pathway
– Antibody-drug Conjugate/ADC Related
Product type
– ADC Related
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
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