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Deferoxamine
Price range: 102 CAD through 1,530 CAD
Products Details
Product Description
– Deferoxamine(Desferrioxamine B) is an iron chelator (binds Fe(III) and many other metal cations) that inhibits neuronopathy, may be used to modify the reduction of iron accumulation and deposition in tissues, and may improve neurological dysfunction by inhibiting ferroptosis and neuroinflammation following traumatic brain injury.Desferrioxamin-B has antioxidant, antiproliferative, Deferoxamine has antioxidant, antiproliferative, and antitumor activities, and can induce HIF-1α production, apoptosis and autophagy in cancer cells.Desferrioxamin-B can be used in the treatment of acute iron toxicity and COVID-19 related diseases.
Web ID
– T124358
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C25H48N6O8
Citations
– 1. Yong Y Y, Yan L, Wang B D, et al.Penthorum chinense Pursh inhibits ferroptosis in cellular and Caenorhabditis elegans models of Alzheimer’s disease.Phytomedicine.2024: 155463.
2. Bian Y, Shan G, Liang J, et al.Retinoic acid receptor alpha inhibits ferroptosis by promoting thioredoxin and protein phosphatase 1F in lung adenocarcinoma.Communications Biology.2024, 7(1): 1-13.
3. Chen H, Hu J, Xiong X, et al.SETD8 inhibits apoptosis and ferroptosis of Ewing’s sarcoma through YBX1/RAC3 axis.Cell Death & Disease.2024, 15(7): 494.
4. Bian Y, Shan G, Bi G, et al.Targeting ALDH1A1 to enhance the efficacy of KRAS-targeted therapy through ferroptosis.Redox Biology.2024: 103361.
References
– Duscher D, et al. Comparison of the Hydroxylase Inhibitor Dimethyloxalylglycine and the Iron Chelator Deferoxamine in Diabetic and Aged Wound Healing. Plast Reconstr Surg. 2017 Mar;139(3):695e-706e.
CAS Number
– 70-51-9
Molecular Weight
– C25H48N6O8
Compound Purity
– 0.9997
SMILES
– O=C(NCCCCCN(O)C(=O)C)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN
Pathway
– Apoptosis|||Autophagy|||Angiogenesis|||Chromatin/Epigenetic|||Oxidation-Reduction
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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