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ON 146040
Price range: 93 CAD through 1,581 CAD
Products Details
Product Description
– ON 146040 is an effective inhibitor of PI3K isoforms with IC50s of 14 and 20 nM for PI3Kα and PI3Kδ, respectively.
Web ID
– T12310
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C24H23N7O3S
References
– Stephen Cosenza, et al. Targeting oncogenic STAT3 and STAT5 signaling with on 146040, a small molecule inhibitor of PI3K α/δ and BCR-ABL. Journal of Clinical Oncology 2014 32:15
CAS Number
– 1404231-34-0
Molecular Weight
– C24H23N7O3S
Compound Purity
– 0.9989
SMILES
– CN1CCN(CC1)c1ccc(Nc2ncc3NC(=O)C(Sc3n2)=Cc2ccc(cc2)[N+]([O-])=O)cc1
Target
– GSK-3
Pathway
– Angiogenesis|||Cytoskeletal Signaling|||PI3K/Akt/mTOR signaling|||Tyrosine Kinase/Adaptors
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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