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MD-224
Price range: 102 CAD through 2,160 CAD
Products Details
Product Description
– MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.
Web ID
– T11980
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C48H43Cl2FN6O6
References
– Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis TargetingChimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable TumorRegression. J Med Chem. 2019 Jan 24;62(2):448-466
CAS Number
– 2136247-12-4
Molecular Weight
– C48H43Cl2FN6O6
Compound Purity
– 0.9907
SMILES
– O=C1[C@@]2([C@]3(N[C@@H](C(NC4=CC=C(C(NCCCC#CC5=C6C(C(=O)N(C6)C7C(=O)NC(=O)CC7)=CC=C5)=O)C=C4)=O)[C@@H]2C8=C(F)C(Cl)=CC=C8)CCCCC3)C=9C(N1)=CC(Cl)=CC9
Target
– ALK|||TGF-beta/Smad
Pathway
– Ubiquitination|||Apoptosis|||PROTAC
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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