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JAK3 covalent inhibitor-1
Price range: 5,920 CAD through 9,856 CAD
Products Details
Product Description
– JAK3 Covalent Inhibitor-1 is a compound characterized by its potent and selective inhibition of Janus kinase 3 (JAK3), possessing an IC50 of 11 nM and demonstrating a 246-fold selectivity compared to other JAKs.
Web ID
– T11709
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C22H17FN6O2S
References
– Casimiro-Garcia A, et al. Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors. J Med Chem. 2018 Dec 13;61(23):10665-10699.
CAS Number
– 2300106-50-5
Molecular Weight
– C22H17FN6O2S
SMILES
– N(C#N)[C@@H]1C=2C([C@H](NS(=O)(=O)C3=CC(F)=CC=C3)C1)=CC=C(C2)C4=C5C(=NC=N4)NC=C5
Target
– Others
Pathway
– JAK/STAT signaling|||Angiogenesis|||Chromatin/Epigenetic|||Stem Cells|||Tyrosine Kinase/Adaptors
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
