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Products Details
Product Description
– Ethacrynic acid, a diuretic, functions as an inhibitor of L-type voltage-dependent and store-operated calcium channels, facilitating the relaxation of airway smooth muscle (ASM) cells. It exhibits anti-inflammatory effects, notably reducing retinoid-induced ear edema in mice, and inhibits glutathione S-transferases (GSTs), making it a potent suppressor of the NF-kB signaling pathway. Additionally, ethacrynic acid modulates leukotriene formation. A variant, Ethacrynic acid D5, is distinguished by its deuterium labeling.
Web ID
– T11240
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C13H12Cl2O4
References
– Li XQ, et al. Metabolism of Strained Rings: Glutathione S-transferase-Catalyzed Formation of a Glutathione-Conjugated Spiro-azetidine without Prior Bioactivation. Drug Metab Dispos. 2019 Nov;47(11):1247-1256.
CAS Number
– 1330052-59-9
Molecular Weight
– C13H12Cl2O4
SMILES
– C(C(C(C([2H])([2H])[2H])([2H])[2H])=C)(=O)C1=C(Cl)C(Cl)=C(OCC(O)=O)C=C1
Target
– Influenza Virus|||TLR
Product type
– Isotope products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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