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DM4-SMe
Price range: 2,048 CAD through 3,376 CAD
Products Details
Product Description
– DM4-SMe is a cytotoxic part of antibody-drug conjugates (ADCs) and a metabolite of antibody-maytansin conjugates (AMCs) and tubulin inhibitors, which can also be stabilized by disulfide bonds or thioether The bond binds to the antibody. The IC50 of DM4-SMe on KB cells was 0.026 nM.
Web ID
– T11059
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C39H56ClN3O10S2
References
– Widdison W, et al. Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. Mol Pharm. 2015 Jun 1;12(6):1762-73.
CAS Number
– 796073-68-2
Molecular Weight
– C39H56ClN3O10S2
SMILES
– [H][C@@]12C[C@@](O)(NC(=O)O1)[C@]([H])(OC)C=C/C=C(C)Cc1cc(OC)c(Cl)c(c1)N(C)C(=O)C[C@]([H])(OC(=O)[C@H](C)N(C)C(=O)CCC(C)(C)SSC)[C@]1(C)O[C@H]1[C@@H]2C
Target
– Apoptosis|||MRP|||RAAS
Pathway
– Antibody-drug Conjugate/ADC Related
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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