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Capsaicin
Price range: 80 CAD through 120 CAD
Products Details
Product Description
– Capsaicin ((E)-Capsaicin) is a natural product extracted from Capsicum annuum, and is a TRPV1 agonist (EC50=0.29 μM). Capsaicin has antitumor, anti-inflammatory, antioxidant and neuroprotective activities.
Web ID
– T1062
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C18H27NO3
Citations
– 1. Lu J, Zhou W, Dou F, et al. TRPV1 sustains microglial metabolic reprogramming in Alzheimer’s disease. EMBO reports. 2021, 22(6): e52013.
2. Lu J, Wang C, Cheng X, et al. A breakdown in microglial metabolic reprogramming causes internalization dysfunction of α-synuclein in a mouse model of Parkinson’s disease. Journal of Neuroinflammation. 2022, 19(1): 1-21
3. Wang C, Huang W, Lu J, et al. TRPV1-Mediated Microglial Autophagy Attenuates Alzheimer’s Disease-Associated Pathology and Cognitive Decline. Frontiers in Pharmacology. 2021, 12: 763866-763866.
4. Wang C, Huang W, Lu J, et al. TRPV1-Mediated Microglial Autophagy Attenuates Alzheimer’s Disease-Associated Pathology and Cognitive Decline. Frontiers in Pharmacology. 2021, 12
5. Tang K, Zhang X, Guo Y. Identification of the dietary supplement capsaicin as an inhibitor of Lassa virus entry. Acta Pharmaceutica Sinica B. 2020
6. Xia J, Gu L, Guo Y, et al. Gut Microbiota Mediates the Preventive Effects of Dietary Capsaicin Against Depression-Like Behavior Induced by Lipopolysaccharide in Mice. Frontiers in Cellular and Infection Microbiology. 2021, 11.
7. Wang C, Lu J, Sha X, et al.TRPV1 regulates ApoE4-disrupted intracellular lipid homeostasis and decreases synaptic phagocytosis by microglia.Experimental & Molecular Medicine.2023: 1-17.
8. Lu J, Wu K, Sha X, et al.TRPV1 alleviates APOE4-dependent microglial antigen presentation and T cell infiltration in Alzheimer’s disease.Translational Neurodegeneration.2024, 13(1): 52.
9. Sha X, Lin J, Wu K, et al.The TRPV1-PKM2-SREBP1 axis maintains microglial lipid homeostasis in Alzheimer’s disease.Cell Death & Disease.2025, 16(1): 14.
10. The TRPV1-PKM2-SREBP1 axis maintains microglial lipid homeostasis in Alzheimer’s disease[J]. Cell Death & Disease, 2025, 16(1): 14.
References
– Le TD, et al. Capsaicin-induced apoptosis of FaDu human pharyngeal squamous carcinoma cells. Yonsei Med J. 2012 Jul 1;53(4):834-4doi: 10.3349/ymj.2012.53.4.834. Erratum in: Yonsei Med J. 2012 Nov 1;53(6):1228.
CAS Number
– 404-86-4
Molecular Weight
– C18H27NO3
Compound Purity
– 0.9927
SMILES
– C(NC(CCCC/C=C/C(C)C)=O)C1=CC(OC)=C(O)C=C1
Target
– Thyroid hormone receptor(THR)
Pathway
– Autophagy|||Apoptosis|||Membrane transporter/Ion channel
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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