Retinoic acid
Add to CompareAdded to Compare

Download Files:

Retinoic acid

SKU T1051-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 53 CAD through 80 CAD

Products Details

Product Description

– Retinoic acid (Tretinoin), a metabolite of vitamin A, is a natural agonist of the retinoic acid receptor RAR and inhibits RARα/β/γ (IC50=14 nM). Retinoic acid induces cellular differentiation, reduces cellular proliferation, and inhibits tumorigenesis.

Web ID

– T1051

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C20H28O2

Citations

– 1. Qiu Y, Sun Y, Xu D, et al. Screening of FDA-approved drugs identifies sutent as a modulator of UCP1 expression in brown adipose tissue. EBioMedicine. 2018, 37: 344-355. 2. Wang Y, Dou X, Jiang L, et al. Discovery of novel glycogen synthase kinase-3α inhibitors: Structurebased virtual screening, preliminary SAR and biological evaluation for treatment of acute myeloid leukemia. European Journal of Medicinal Chemistry. 2019, 171: 221-234 3. Wei Z, Li T, Sun Y, et al. Daturataturin A, a withanolide in Datura metel L., induces HaCaT autophagy through the PI3K‐Akt‐mTOR signaling pathway. Phytotherapy Research. 2021 Mar;35(3):1546-1558. doi: 10.1002/ptr.6921. Epub 2021 Feb 9. 4. Wan X Q, Cai J Y, Zhu Y, et al. SENP1 has an important role in lung development and influences the differentiation of alveolar type 2 cells. International journal of molecular medicine. 2019 Jan;43(1):371-381. 5. Zhu Y, Gu X, Wang L, et al.All-Trans Retinoic Acid Promotes M2 Macrophage Polarization in Vitro by Activating the p38MAPK/STAT6 Signaling Pathway.Immunological Investigations.2023: 1-21. 6. Dou X, Huo T, Liu Y, et al.Discovery of novel and selective farnesoid X receptor antagonists through structure-based virtual screening, preliminary structure-activity relationship study, and biological evaluation.European Journal of Medicinal Chemistry.2024: 116323.

References

– Chen Q, et al. Retinoic acid regulates cell cycle progression and cell differentiation in human monocytic THP-1 cells. Exp Cell Res. 2004 Jul 1;297(1):68-81.

CAS Number

– 302-79-4

Molecular Weight

– C20H28O2

Compound Purity

– 0.996

SMILES

– CC(/C=C/C1=C(C)CCCC1(C)C)=CC=CC(C)=CC(O)=O

Target

– Antifungal

Pathway

– Metabolism|||Autophagy|||DNA Damage/DNA Repair

Product type

– Natural Product

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

Related Products

Select options
4-Methylcinnamic acid
4-Methylcinnamic acid Price range: 46 CAD through 48 CAD
1 g1 mL * 10 mM (in DMSO)

1000 in stock

Select options
Oxindole
Oxindole Price range: 46 CAD through 59 CAD
1 mL * 10 mM (in DMSO)10 g5 g

1000 in stock

Select options
(-)-Isopulegol
(-)-Isopulegol 46 CAD
1 g1 mL * 10 mM (in DMSO)

1000 in stock

Select options
Coumaran
Coumaran 46 CAD
1 mL * 10 mM (in DMSO)5 g

1000 in stock

Select options
Tropinone
Tropinone Price range: 67 CAD through 74 CAD
1 mL * 10 mM (in DMSO)100 mg

1000 in stock

My Cart
Wishlist
Recently Viewed
Categories

Request Data Sheet / Safty Data Sheet

Please enable JavaScript in your browser to complete this form.
=

Price Request

Please enable JavaScript in your browser to complete this form.
=

Compare Products (0 Products)
document.addEventListener('elementor/popup/show', function() { if (typeof turnstile !== 'undefined') { document.querySelectorAll('.cf-turnstile').forEach(function(el) { if (!el.dataset.rendered) { turnstile.render(el); el.dataset.rendered = true; } }); } });