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PROTAC Bcl2 degrader-1
Price range: 730 CAD through 1,984 CAD
Products Details
Product Description
– PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).
Web ID
– T10485
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C45H45BrN6O10S
References
– Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Aug 21.
CAS Number
– 2378801-85-3
Molecular Weight
– C45H45BrN6O10S
SMILES
– O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCCOCCOCCNC(=O)CCCCC(=O)NCCN4C(=O)C5=CC=CC=6C(SC7=CC=C(Br)C=C7)=CC=C(C4=O)C56)C3C2=O)CC1
Target
– Others
Pathway
– PROTAC|||Apoptosis
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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