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Products Details
Product Description
– GSK1614343 is the potent antagonist of growth hormone secretagogues type 1a (GHS1a) receptors. GSK1614343 inhibits the calcium response induced by ghrelin with a pIC50 value of 7.90. GSK1614343 represents a useful tool to investigate the physiological relevance of the ghrelin system in rat models[1].
Web ID
– HY-113906
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C22H23F6N5O
References
– [1]Perdonà E, et al. Pharmacological characterization of the ghrelin receptor antagonist, GSK1614343 in rat RC-4B/C cells natively expressing GHS type 1a receptors. Eur J Pharmacol. 2011;650(1):178-183.
CAS Number
– 1092076-04-4
Molecular Weight
– 487.44
SMILES
– O=C([C@@H](C1=CC=CN=C1)N2C[C@@]3([H])CCCN3CC2)NNC4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– DMSO : ≥ 100 mg/mL
Target
– GHSR
Pathway
– GPCR/G Protein
Product type
– Reference compound
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