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Zymostenol
$85
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Products Details
Product Description
– Zymostenol (5a-Cholest-8-en-3b-ol) is a late-stage precursor in the biosynthesis of cholesterol. Zymostenol is a RORγ agonist (EC50: 1 μM)[1][2][3].
Web ID
– HY-113345
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Molecular Formula
– C27H46O
References
– [1]Hu X, et al. Sterol metabolism controls T(H)17 differentiation by generating endogenous RORγ agonists. Nat Chem Biol. 2015 Feb;11(2):141-7. |[2]Hubler Z, et al. Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination. Nature. 2018 Aug;560(7718):372-376. |[3]Payré B, et al. Microsomal antiestrogen-binding site ligands induce growth control and differentiation of human breast cancer cells through the modulation of cholesterol metabolism. Mol Cancer Ther. 2008 Dec;7(12):3707-18.
CAS Number
– 566-97-2
Molecular Weight
– 386.65
Compound Purity
– 95.0
SMILES
– CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])C(CC[C@@]3([H])C[C@@H](O)CC[C@]43C)=C4CC[C@]12C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Endogenous Metabolite;ROR
Isoform
– Human Endogenous Metabolite;RORγ
Pathway
– Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
