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ZLWT-37
SKU
HY-147771-Get quote
Category Reference compound
Tags Apoptosis;CDK, Apoptosis;Cell Cycle/DNA Damage, Cancer
Products Details
Product Description
– ZLWT-37 is a potent, orally active CDKs inhibitor with IC50 values of 0.002 μM and 0.054 μM against CDK9 and CDK2, respectively. ZLWT-37 induces apoptosis and arrests the cell cycle in the G2/M phase in HCT116 cells[1].
Web ID
– HY-147771
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C26H30ClN5O
References
– [1]Liu W, et al. Discovery of novel tacrine derivatives as potent antiproliferative agents with CDKs inhibitory property. Bioorg Chem. 2022 Sep;126:105875.
CAS Number
– 2813347-44-1
Molecular Weight
– 464.00
SMILES
– N[C@H]1CCN(C1)C2=C3CCCCC3=NC4=C2C=C(C=C4)C5=CC=NC(NC(C6CC6)=O)=C5.Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;CDK
Isoform
– CDK2;CDK9
Pathway
– Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.