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Products Details
Product Description
– ZLHQ-5f is a dual CDK2 and Topo I inhibitor with an IC50 of 0.145 μM against CDK2/CycA2. ZLHQ-5f arrests the cell cycle in S-phase, triggers apoptosis in HCT116 cells, and has a good safety profile[1].
Web ID
– HY-147698
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C28H25N5O2
References
– [1]Huang Y, et al. Discovery of novel benzofuro[3,2-b]quinoline derivatives as dual CDK2/Topo I inhibitors. Bioorg Chem. 2022 May 21;126:105870.
CAS Number
– 2851977-85-8
Molecular Weight
– 463.53
SMILES
– N[C@H]1CCN(C1)C2=C3OC4=C(C3=NC5=CC=C(C=C52)C6=CC(NC(C7CC7)=O)=NC=C6)C=CC=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;CDK;Topoisomerase
Isoform
– CDK2;Topo I
Pathway
– Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
