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Products Details
Product Description
– Considerable studies confirmed that BRD4 inhibition ameliorated kidney injury and fibrosis ，and ZLD2218 exhibited the most potent inhibitory activity against BRD4, with the IC50 value of 107 nM
Web ID
– HY-144236
Shipping
– Room temperature
Molecular Formula
– C22H18N4O
References
– [1]Tao S,et al. Discovery of indol-6-yl-pyrrolo[2,3-c]pyridin-7-one derivatives as bromodomain-containing protein 4 (BRD4) inhibitors for the treatment of kidney fibrosis. Eur J Med Chem. 2022 Mar 5;231:114153.
CAS Number
– 2713974-32-2
Molecular Weight
– 354.40
SMILES
– O=C1C2=C(C(C3=CC4=C(C=CN4CC5=NC=CC=C5)C=C3)=CN1C)C=CN2
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– 10 mM in DMSO
Target
– Epigenetic Reader Domain
Pathway
– Epigenetics
Product type
– Reference compound
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