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Products Details
Product Description
– Ziv-aflibercept is a soluble inhibitor of vascular endothelial growth factor (VEGF). Ziv-aflibercept is an adaptive variant of Aflibercept (HY-108801), Ziv-aflibercept has a low PH value and high osmotic pressure when compared to Aflibercept. Ziv-aflibercept has potential applications in metastatic colorectal carcinoma and retinal diseases[1][2].
Web ID
– HY-108798
Shipping
– Room temperature
Molecular Formula
– N/A
References
– [1]Malik D, et al. Safety profiles of anti-VEGF drugs: bevacizumab, ranibizumab, aflibercept and ziv-aflibercept on human retinal pigment epithelium cells in culture. Br J Ophthalmol. 2014 Jun;98 Suppl 1(Suppl 1):i11-16. |[2]de Oliveira Dias JR, et al. Fusion proteins for treatment of retinal diseases: aflibercept, ziv-aflibercept, and conbercept. Int J Retina Vitreous. 2016 Feb 1;2:3.
CAS Number
– 1609655-49-3
Molecular Weight
– N/A
SMILES
– [Ziv-aflibercept]
Clinical Information
– Launched
Research Area
– Cancer; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– VEGFR
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Inhibitory Antibodies
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
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