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Zidovudine O-β-D-glucuronide (sodium)
$160 – $400
Products Details
Product Description
– Zidovudine O-β-D-glucuronide (3′-Azido-3′-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection[1][2]. Zidovudine O-β-D-glucuronide (sodium) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
Web ID
– HY-137522
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Molecular Formula
– C16H20N5NaO10
References
– [1]Fayz S, et, al. Zidovudine azido-reductase in human liver microsomes: activation by ethacrynic acid, dipyridamole, and indomethacin and inhibition by human immunodeficiency virus protease inhibitors. Antimicrob Agents Chemother. 1998 Jul;42(7):1654-8. |[2]Bélanger AS, et, al. Glucuronidation of the antiretroviral drug efavirenz by UGT2B7 and an in vitro investigation of drug-drug interaction with zidovudine. Drug Metab Dispos. 2009 Sep;37(9):1793-6.
CAS Number
– 133525-01-6
Molecular Weight
– 465.35
Compound Purity
– 99.05
SMILES
– O=C(NC1=O)N(C=C1C)[C@](C[C@@H]2N=[N+]=[N-])([H])O[C@@H]2CO[C@@H]([C@@H]([C@H]3O)O)O[C@@H]([C@H]3O)C(O[Na])=O
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Drug Metabolite
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
