Download Files:
Zenidolol (hydrochloride)
$61 – $540
Products Details
Product Description
– Zenidolol (ICI-118551) hydrochloride is a highly selective β2 adrenergic receptor antagonist, with Kis of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively.
Web ID
– HY-13951
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C17H28ClNO2
Citations
– Biomed Pharmacother. 2023 Mar 15;161:114523.|bioRxiv. 2020 Jan.|BMC Ophthalmol. 2021 Dec 5;21(1):419.|BMC Cancer. 2019 Nov 26;19(1):1142.|Br J Pharmacol. 2020 Jan;177(2):282-297. |Commun Biol. 2021 Dec 3;4(1):1359.|Commun Biol. 2022 Apr 8;5(1):339.|Environ Toxicol. 2023 Dec 2.|Eur J Pharmacol. 2022 Jun 20;175110.|Int J Biol Sci. 2023 Apr 2,19.|J Exp Clin Cancer Res. 2019 Apr 25;38(1):174. |J Exp Med. 2023 Nov 6;220(11):e20230577.|J Nutr Biochem. 2018 May 1;58:110-118.|J Oral Maxillofac Surg. 2020 Oct;78(10):1871.e1-1871.e23.|Mol Oncol. 2022 May 20.|Nat Commun. 2020 Sep 25;11(1):4857.|Nat Commun. 2021 Nov 26;12(1):6937.|Neuroscience. 2019 Mar 1;401:59-72. |Oncol Rep. 2016 Sep;36(3):1576-84. |Pflugers Arch. 2021 Sep 26.|Research Square Preprint. 2020 Oct.|Research Square Preprint. 2021 Feb.|Research Square Preprint. 2021 Nov.|Research Square Preprint. 2021 Sep.|Research Square Preprint. 2022 Mar.|J Endocrinol. 2023 Feb 16;256(3):e220335.|Nat Commun. 2023 May 2;14(1):2523.
References
– [1]Hoffmann C, et al. Comparative pharmacology of human beta-adrenergic receptor subtypes–characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):151-9.|[2]Yasuda G, et al. The beta 1- and beta 2-adrenoceptor subtypes in cultured rat inner medullary collecting duct cells. Am J Physiol. 1996 Sep;271(3 Pt 2):F762-9.|[3]Wenzel D, et al. beta(2)-adrenoceptor antagonist ICI 118,551 decreases pulmonary vascular tone in mice via a G(i/o) protein/nitric oxide-coupled pathway. Hypertension. 2009 Jul;54(1):157-63.|[4]Gong H, et al. Specific beta(2)AR blocker ICI 118,551 actively decreases contraction through a G(i)-coupled form of the beta(2)AR in myocytes from failing human heart. Circulation. 2002 May 28;105(21):2497-503.
CAS Number
– 72795-01-8
Molecular Weight
– 313.86
Compound Purity
– 99.76
SMILES
– CC1=C(CCC2)C2=C(OC[C@H](O)[C@@H](C)NC(C)C)C=C1.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Neurological Disease; Endocrinology
Solubility
– DMSO : 33.33 mg/mL (ultrasonic)|H2O : 12.5 mg/mL (ultrasonic)
Target
– Adrenergic Receptor
Isoform
– β adrenergic receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
