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Zelavespib

SKU HY-11038-10 mg Category Reference compound Tags Cancer, Cell Cycle/DNA Damage;Metabolic Enzyme/Protease, HSP

$69 – $900

Size

5 mg 10mM/1mL 10 mg 50 mg 100 mg

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Products Details

Product Description

– Zelavespib (PU-H71) is a potent Hsp90 inhibitor, with an IC50 of 51 nM in MDA-MB-468 cells.

Web ID

– HY-11038

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Cancer-Kinase/protease

Molecular Formula

– C18H21IN6O2S

References

– [1]Caldas-Lopes E, et al. Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. Proc Natl Acad Sci U S A. 2009 May 19;106(20):8368-73.|[2]Guo A, et al. HSP90 stabilizes B-cell receptor kinases in a multi-client interactome: PU-H71 induces CLL apoptosis in a cytoprotective microenvironment. Oncogene. 2017 Jun 15;36(24):3441-3449.|[3]Qu Z, et al. PU-H71 effectively induces degradation of IκB kinase β in the presence of TNF-α. Mol Cell Biochem. 2014 Jan;386(1-2):135-42.

CAS Number

– 873436-91-0

Molecular Weight

– 512.37

Compound Purity

– 99.90

SMILES

– CC(C)NCCCN1C(SC2=C(C=C3OCOC3=C2)I)=NC4=C(N=CN=C14)N

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– DMSO : ≥ 100 mg/mL

Target

– HSP

Isoform

– HSP90

Pathway

– Cell Cycle/DNA Damage;Metabolic Enzyme/Protease

Product type

– Reference compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.