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Products Details
Product Description
– ZDWX-25 is a highly potent GSK-3β and DYRK1A dual inhibitor with an IC50 value of 71 nM for GSK-3β. ZDWX-25 possesses significant cytotoxic activities against SH-SY5Y and HL-7702 cells. ZDWX-25 can be used for researching alzheimer’s disease[1].
Web ID
– HY-144826
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C17H15N3O3
References
– [1]Liu W, et al. Discovery of novel β-carboline derivatives as selective AChE inhibitors with GSK-3β inhibitory property for the treatment of Alzheimer’s disease. Eur J Med Chem. 2022;229:114095.
CAS Number
– 2668297-70-7
Molecular Weight
– 309.32
SMILES
– COC(C1=CC=C2C(NC3=C(N=CC=C23)NC(C4CC4)=O)=C1)=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– GSK-3
Isoform
– GSK-3β
Pathway
– PI3K/Akt/mTOR;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
