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ZAP-180013
$80 – $720
Products Details
Product Description
– ZAP-180013 is a zeta-chain-associated protein kinase 70 (ZAP-70) inhibitor with an IC50 of 1.8 μM. ZAP-180013 inhibits the interaction of ZAP-70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs)[1].
Web ID
– HY-136179
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– COVID-19-immunoregulation
Molecular Formula
– C19H17Cl2N3O4S
References
– [1]Patrick R Visperas, et al. Identification of Inhibitors of the Association of ZAP-70 With the T Cell Receptor by High-Throughput Screen. SLAS Discov. 2017 Mar;22(3):324-331.
CAS Number
– 873080-25-2
Molecular Weight
– 454.33
Compound Purity
– 99.79
SMILES
– O=C(C1=NC(S(=O)(CC)=O)=NC=C1Cl)N(CC2=CC=C(Cl)C=C2)CC3=CC=CO3
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– Tyrosinase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
