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Products Details
Product Description
– Zalypsis (PM00104) has anti-tumor activity. Zalypsis binds to DNA and shows cytotoxicity. Zalypsis inhibits cell cycle and transcription, and leads to double stranded DNA breaks[1][2].
Web ID
– HY-16401
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C37H38F3N3O8
References
– [1]Duan Z, et al. Diverse cross-resistance phenotype to ET-743 and PM00104 in multi-drug resistant cell lines. Cancer Chemother Pharmacol. 2009 May;63(6):1121-9.|[2]Petek BJ, et al. PM00104 (Zalypsis®): a marine derived alkylating agent. Molecules. 2014 Aug 15;19(8):12328-35.
CAS Number
– 308359-57-1
Molecular Weight
– 709.71
SMILES
– O=C(NC[C@H]1C2=C3C(OCO3)=C(C)C(OC(C)=O)=C2C[C@]4([H])N1[C@@H](O)[C@@]5([H])N(C)[C@]4([H])C6=C(C5)C=C(C)C(OC)=C6O)/C=C/C7=CC(C(F)(F)F)=CC=C7
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
