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Products Details
Product Description
– YW2065 is an Axin-1 stabilizer. Axin-1 is a scaffolding protein that regulates proteasome degradation of β-catenin. YW2065 exhibits anti-colorectal cancer effects via dual activities of wnt/β-catenin signaling inhibition and AMPK activation[1].
Web ID
– HY-141543
Shipping
– Room temperature
Molecular Formula
– C20H15BrN4O
References
– [1]Yang W, et, al. Pyrazole-4-Carboxamide (YW2065): A Therapeutic Candidate for Colorectal Cancer via Dual Activities of Wnt/β-Catenin Signaling Inhibition and AMP-Activated Protein Kinase (AMPK) Activation. J Med Chem. 2019 Dec 26;62(24):11151-11164.
CAS Number
– 2131223-85-1
Molecular Weight
– 407.26
SMILES
– O=C(C1=C(C)N(C2=CC=CC=C2Br)N=C1)NC3=NC4=CC=CC=C4C=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– β-catenin
Pathway
– Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
