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Products Details
Product Description
– YW2065 is an Axin-1 stabilizer. Axin-1 is a scaffolding protein that regulates proteasome degradation of β-catenin. YW2065 exhibits anti-colorectal cancer effects via dual activities of wnt/β-catenin signaling inhibition and AMPK activation[1].
Web ID
– HY-141543
Shipping
– Room temperature
Molecular Formula
– C20H15BrN4O
References
– [1]Yang W, et, al. Pyrazole-4-Carboxamide (YW2065): A Therapeutic Candidate for Colorectal Cancer via Dual Activities of Wnt/β-Catenin Signaling Inhibition and AMP-Activated Protein Kinase (AMPK) Activation. J Med Chem. 2019 Dec 26;62(24):11151-11164.
CAS Number
– 2131223-85-1
Molecular Weight
– 407.26
SMILES
– O=C(C1=C(C)N(C2=CC=CC=C2Br)N=C1)NC3=NC4=CC=CC=C4C=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– β-catenin
Pathway
– Stem Cell/Wnt
Product type
– Reference compound
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