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YS121
$554
Only 1000 item(s) left in stock.
Products Details
Product Description
– YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1; IC50=3.4 μM) and 5-lipoxygenase (5-LOX; IC50=6.5 μM). YS121 dose- dependently reduces PGE2 production with EC50=12 μM in IL-1β-stimulated A549 cells[1].
Web ID
– HY-111140
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C20H26ClN3O2S
References
– [1]Hui-Hua Chang, et al. Identification and development of mPGES-1 inhibitors: where we are at?. Future Med Chem. 2011 Nov;3(15):1909-34.
CAS Number
– 916482-17-2
Molecular Weight
– 407.96
SMILES
– CCCCCCC(SC1=NC(NC2=CC=CC(C)=C2C)=CC(Cl)=N1)C(O)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Lipoxygenase;PGE synthase
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
