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Products Details
Product Description
– YS-363 is a potent, selective, and orally active EGFR inhibitor, with IC50s of 0.96 nM and 0.67 nM for wild-type and L858R mutant forms of EGFR, respectively. YS-363 can induce G0/G1 cell cycle arrest and apoptosis[1].
Web ID
– HY-155285
Shipping
– Room temperature
Molecular Formula
– C30H30N4O3
References
– [1]He P, et, al. Discovery of YS-363 as a highly potent, selective, and orally efficacious EGFR inhibitor. Biomed Pharmacother. 2023 Nov:167:115491.
CAS Number
– 2470908-90-6
Molecular Weight
– 494.58
SMILES
– COC1=C(OCCCN2CCOCC2)C=C3C(N=CN=C3C4=C(C5=CC=CC=C5)NC6=C4C=CC=C6)=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;EGFR
Isoform
– EGFR/ErbB1/HER1
Pathway
– Apoptosis;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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