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Products Details
Product Description
– YM458 is a potent EZH2 and BRD4 dual inhibitor with IC50s of 490 nM and 34 nM, respectively. YM458 inhibits cell proliferation and colony formation and induces cell cycle arrest and apoptosis in solid cancer cells. YM458 can be used for researching anticancer[1].
Web ID
– HY-146999
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C53H61ClN8O5S
References
– [1]Guo Z, et al. Design and Synthesis of Dual EZH2/BRD4 Inhibitors to Target Solid Tumors. J Med Chem. 2022;65(9):6573-6592.
CAS Number
– 2770108-93-3
Molecular Weight
– 957.62
SMILES
– CC1=C(C2=C(S1)N3C([C@@H](N=C2C4=CC=C(C=C4)Cl)CC(NCCCCCOC5=CC=C(C6=CC(N(CC)C7CCOCC7)=C(C(C(NCC8=C(C=C(NC8=O)C)C)=O)=C6)C)C=C5)=O)=NN=C3C)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Epigenetic Reader Domain;Histone Methyltransferase
Isoform
– BRD4;EZH2
Pathway
– Apoptosis;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
