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Products Details
Product Description
– YM281 is a potent EZH2 inhibitor. YM281 induces cell apoptosis and cell cycle arrest at the G0/G1 phase. YM281 shows antitumor effects in vivo. YM281 has the potential for the research of lymphoma[1].
Web ID
– HY-145762
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C56H71N7O9S
References
– [1]Tu Y,et al. Design, Synthesis, and Evaluation of VHL-Based EZH2 Degraders to Enhance Therapeutic Activity against Lymphoma. J Med Chem. 2021 Jul 22;64(14):10167-10184.
CAS Number
– 2230914-84-6
Molecular Weight
– 1018.27
SMILES
– CCN(C1CCOCC1)C2=CC(C3=CC=C(C=C3)OCCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(NCC5=CC=C(C6=C(N=CS6)C)C=C5)=O)=O)=O)=CC(C(NCC7=C(C=C(NC7=O)C)C)=O)=C2C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Histone Methyltransferase
Isoform
– EZH2
Pathway
– Apoptosis;Epigenetics
Product type
– Reference compound
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