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Products Details
Product Description
– YL5084, a covalent JNK inhibitor, exhibits selectivity for JNK2 and JNK3 over JNK1 with IC50s of 70 nM, 84 nM and 2173 nM, respectively. YL5084 exhibits JNK2-independent antiproliferative effects and induces apoptosis in a JNK2-independent manner[1].
Web ID
– HY-149930
Shipping
– Room temperature
Molecular Formula
– C35H36N8O2
References
– [1]Wenchao Lu, et al. Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1. J Med Chem. 2023 Mar 9;66(5):3356-3371.
CAS Number
– 2440199-73-3
Molecular Weight
– 600.71
SMILES
– O=C(C1=CC=C(C=C1)NC(/C=C/CN(C)C)=O)N(C[C@@H]2C)C[C@H]2NC3=NC=CC(C4=C(C=CC=C5)N5N=C4C6=CC=CC=C6)=N3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;JNK
Isoform
– JNK1;JNK2;JNK3
Pathway
– Apoptosis;MAPK/ERK Pathway
Product type
– Reference compound
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