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YHO-13351 (free base)
$100 – $750
Products Details
Product Description
– YHO-13351 free base is the prodrug of YHO-13177, which is a potent and specific inhibitor of BCRP.
Web ID
– HY-12758A
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C26H33N3O4S
References
– [1]Yamazaki R, et al. Novel acrylonitrile derivatives, YHO-13177 and YHO-13351, reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo. Mol Cancer Ther. 2011 Jul;10(7):1252-63.|[2]Shishido Y, et al. ABCG2 inhibitor YHO-13351 sensitizes cancer stem/initiating-like side population cells to irinotecan. Anticancer Res. 2013 Apr;33(4):1379-86.
CAS Number
– 912288-64-3
Molecular Weight
– 483.62
Compound Purity
– 99.00
SMILES
– N#C/C(C1=CC=C(OC)C(OC)=C1)=CC2=CC=C(N3CCC(OC(CN(CC)CC)=O)CC3)S2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– BCRP
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
