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Products Details
Product Description
– YCH1899 is an orally active PARP inhibitor, with an IC50< 0.001 nM for PARP1/2. YCH1899 exhibits distinct antiproliferation activity against Olaparib (HY-10162)-resistant and Talazoparib (HY-16106)-resistant Capan-1 cells (Capan-1/OP and Capan-1/TP cells) , with IC50 values of 0.89 and 1.13 nM, respectively. YCH1899 has acceptable pharmacokinetic properties in rats[1].
Web ID
– HY-155993
Shipping
– Room temperature
Molecular Formula
– C25H18BrFN6O3
References
– [1]Sun Y, et al. YCH1899, a Highly Effective Phthalazin-1(2H)-one Derivative That Overcomes Resistance to Prior PARP Inhibitors. J Med Chem. 2023 Aug 21.
Molecular Weight
– 549.35
SMILES
– O=C1NN=C(C2=CC=CC=C21)CC3=CC=C(C(C(N4CCN5C(C4)=NN=C5C6=CC=C(O6)Br)=O)=C3)F
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– PARP
Isoform
– PARP1;PARP10;PARP12;PARP14;PARP15;PARP2;PARP3;PARP4;PARP7;TNKS1/PARP5A;TNKS2/PARP5B
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
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