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Products Details
Product Description
– Y134 is a selective and orally active oestrogen receptor (ER) modulator (SERM), exhibits potent antagonist activity at ERα and ERβ. Y134 shows 121.1-fold selectivity for ERα (Ki=0.09 nM) over ERβ (Ki=11.31 nM). Y134 inhibits oestrogen-stimulated proliferation of ER-positive human breast cancer cells[1].
Web ID
– HY-103457
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C28H28N2O3S
References
– [1]Ning M, et, al. Biological activities of a novel selective oestrogen receptor modulator derived from raloxifene (Y134). Br J Pharmacol. 2007 Jan;150(1):19-28.
CAS Number
– 849662-80-2
Molecular Weight
– 472.60
SMILES
– O=C(C1=C(C2=CC=C(O)C=C2)SC3=CC(O)=CC=C31)C4=CC=C(N5CCN(C(C)C)CC5)C=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Estrogen Receptor/ERR
Isoform
– ERα;ERβ
Pathway
– Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
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