Products Details

Product Description

– XR11576 (MLN576) is an orally active inhibitor of topoisomerase I and II. XR11576 shows cytotoxicity against human and murine tumor cell lines (IC50: 6-47 nM)[1].

Web ID

– HY-123143

Shipping

– Room temperature

Molecular Formula

– C23H24N4O2

References

– [1]Di Nicolantonio F, et al. Ex vivo characterization of XR11576 (MLN576) against ovarian cancer and other solid tumors. Anticancer Drugs. 2004 Oct;15(9):849-60.|[2]Mistry P, et al. In vitro and in vivo characterization of XR11576, a novel, orally active, dual inhibitor of topoisomerase I and II. Anticancer Drugs. 2002 Jan;13(1):15-28.

CAS Number

– 346689-77-8

Molecular Weight

– 388.46

SMILES

– O=C(N[C@@H](CN(C)C)C)C1=C2C(N=C3C=CC4=C(C=CC=C4C3=N2)OC)=CC=C1

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– Topoisomerase

Pathway

– Cell Cycle/DNA Damage

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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