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Products Details
Product Description
– XPO1-IN-1 (compound D4) is an orally active and potent XPO1 inhibitor, with an IC50 of 24 nM in MM.1S cell. XPO1-IN-1 can efficiently induce cell apoptosis and cell cycle arrest. XPO1-IN-1 displays favorable metabolic stability and pharmacokinetic properties. XPO1-IN-1 can be used for multiple myeloma (MM) research[1].
Web ID
– HY-144763
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C20H15F6N5O3S
References
– [1]Qu B, et al. Design, synthesis and biological evaluation of sulfonamides inhibitors of XPO1 displaying activity against multiple myeloma cells. Eur J Med Chem. 2022;235:114257.
Molecular Weight
– 519.42
SMILES
– CS(=O)(NC1=CC=C(C=C1)/C(C(N)=O)=CN2C=NC(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=N2)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
