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XCT790
SKU
HY-10426-10 mg
Category Reference compound
Tags Autophagy;Estrogen Receptor/ERR, Autophagy;Vitamin D Related/Nuclear Receptor, Cancer
$75 – $418
Products Details
Product Description
– XCT-790 is a potent and selective inverse agonist for ERRα with an IC50 value of 0.37 μM. XCT-790 induces cell death in chemotherapeutic resistant cancer cells. XCT-790 (Compound 12) is inactive against ERRγ and the estrogen receptors ERα and ERβ[1][2].
Web ID
– HY-10426
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C23H13F9N4O3S
References
– [1]Kokabu T, et al. Antitumor effect of XCT790, an ERRα inverse agonist, on ERα-negative endometrial cancer cells. Cell Oncol (Dordr). 2019 Apr;42(2):223-235.|[2]Wu F, et al. Estrogen-related receptor alpha (ERRalpha) inverse agonist XCT-790 induces cell death in chemotherapeutic resistant cancer cells. Chem Biol Interact. 2009 Oct 7;181(2):236-42.|[3]Busch BB, et al. Identification of a selective inverse agonist for the orphan nuclear receptor estrogen-related receptor alpha. J Med Chem. 2004 Nov 4;47(23):5593-6.
CAS Number
– 725247-18-7
Molecular Weight
– 596.42
Compound Purity
– 99.54
SMILES
– O=C(NC1=NN=C(C(F)(F)F)S1)/C(C#N)=C/C2=CC=C(OCC3=C(C(F)(F)F)C=C(C(F)(F)F)C=C3)C(OC)=C2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 16.67 mg/mL (ultrasonic)
Target
– Autophagy;Estrogen Receptor/ERR
Isoform
– ERRα
Pathway
– Autophagy;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
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