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Products Details
Product Description
– WR99210 hydrochloride is an orally active and low-toxicity dihydrofolate reductase (DHFR) inhibitor (IC50P. falciparum and P. falciparum strains as well as T. gondii[1][2][3].
Web ID
– HY-116387A
Shipping
– Room temperature
Molecular Formula
– C14H19Cl4N5O2
References
– [1]Mui EJ, et al. Triazine Inhibits Toxoplasma gondii tachyzoites in vitro and in vivo. Antimicrob Agents Chemother. 2005 Aug;49(8):3463-7. |[2]Hastings MD, et al. Pyrimethamine and WR99210 exert opposing selection on dihydrofolatereductase from Plasmodium vivax. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13137-41.|[3]Kiara SM, et al. In vitro activity of antifolate and polymorphism in dihydrofolate reductase of <i>Plasmodium falciparum</i> isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation. Antimicrob Agents Chemother. 2009 Sep;53(9):3793-8.
CAS Number
– 30711-93-4
Molecular Weight
– 431.14
SMILES
– CC1(N=C(N=C(N1OCCCOC2=C(C=C(C(Cl)=C2)Cl)Cl)N)N)C.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Dihydrofolate reductase (DHFR) ;Parasite
Pathway
– Anti-infection;Metabolic Enzyme/Protease
Product type
– Reference compound
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