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WDR5-IN-4 (TFA)
$350 – $550
Products Details
Product Description
– WDR5-IN-4 TFA is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5), with a Kd of 0.1 nM. WDR5-IN-4 TFA displaces WDR5 from chromatin and decreases the expression of associated genes, causing translational inhibition, nucleolar stress. Anti-cancer activity[1].
Web ID
– HY-111753A
Storage Temperature
– 4°C (Powder, stored under nitrogen, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C27H23Cl2F4N5O3
Citations
– bioRxiv. 2023 Jun 5.|Cell Rep. 2023 Apr 21;42(5):112423.
References
– [1]Aho ER, et al. Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep. 2019 Mar 12;26(11):2916-2928.e13.
CAS Number
– 2749300-35-2
Molecular Weight
– 612.40
Compound Purity
– 99.87
SMILES
– ClC1=CC=C(CNC(C2=CC(CN3C(N(C)C=C3)=N)=CC(C4=C(C)N=C(F)C=C4)=C2)=O)C=C1Cl.O=C(O)C(F)(F)F
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 250 mg/mL
Target
– Histone Methyltransferase
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
