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Products Details
Product Description
– WDR5-IN-4 is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5), with a Kd of 0.1 nM. WDR5-IN-4 displaces WDR5 from chromatin and decreases the expression of associated genes, causing translational inhibition, nucleolar stress. Anti-cancer activity[1].
Web ID
– HY-111753
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C25H22Cl2FN5O
Citations
– Cell Rep. 2023 Apr 21;42(5):112423.|bioRxiv. 2023 Jun 5.
References
– [1]Aho ER, et al. Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep. 2019 Mar 12;26(11):2916-2928.e13.
CAS Number
– 2407457-36-5
Molecular Weight
– 498.38
SMILES
– ClC1=CC=C(CNC(C2=CC(CN3C(N(C)C=C3)=N)=CC(C4=C(C)N=C(F)C=C4)=C2)=O)C=C1Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Histone Methyltransferase
Pathway
– Epigenetics
Product type
– Reference compound
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