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Products Details
Product Description
– VU0469650 is a potent, selective and CNS-penetrated negative allosteric modulator of mGlu1 receptor, with an IC50 of 99 nM[1].
Web ID
– HY-110191
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C22H28N4O
References
– [1]Lovell KM, Felts AS, Rodriguez AL, et al. N-Acyl-N’-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in rats. Bioorg Med Chem Lett. 2013;23(13):3713-3718.
CAS Number
– 1443748-47-7
Molecular Weight
– 364.48
SMILES
– O=C(N1[C@@H](CN(C2=C(N=CC=C2)C#N)CC1)C)C34C[C@H](C5)C[C@H](C[C@H]5C4)C3
Clinical Information
– No Development Reported
Research Area
– Cancer; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– mGluR
Isoform
– mGluR1
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
