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VU0463271 (quarterhydrate)
$250
Only 1000 item(s) left in stock.
Products Details
Product Description
– VU0463271 quarterhydrate is a potent KCC2 antagonist, with an IC50 of 61 nM[1].
Web ID
– HY-110110A
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C19H18N4OS2.1/4H2O
References
– [1]Delpire E, et al. Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4532-5.|[2]Rui Chen, et al. Functional Coupling of K +-Cl – Cotransporter (KCC) to GABA-Gated Cl – Channels in the Central Nervous System of Drosophila melanogaster Leads to Altered Drug Sensitivities. ACS Chem Neurosci. 2019 Jun 19;10(6):2765-2776.
Molecular Weight
– 387.00
Compound Purity
– 98.0
SMILES
– O=C(N(C1CC1)C2=NC(C)=CS2)CSC3=NN=C(C4=CC=CC=C4)C=C3.[1/4].O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 19 mg/mL (ultrasonic;warming)
Target
– Potassium Channel
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
