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Products Details
Product Description
– VT-1598 tosylate is an orally active and selective fungal inhibitor targeting CYP51. VT-1598 tosylate shows anti-fungal activity against C. auris[1][2]. VT-1598 (tosylate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Web ID
– HY-123777A
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C38H28F4N6O5S
References
– [1]Nathan P Wiederhold, et al. The Fungal Cyp51-Specific Inhibitor VT-1598 Demonstrates In Vitro and In Vivo Activity against Candida auris. Antimicrob Agents Chemother. 2019 Feb 26;63(3):e02233-18.|[2]Timothy J Break, et al. VT-1598 inhibits the in vitro growth of mucosal Candida strains and protects against fluconazole-susceptible and -resistant oral candidiasis in IL-17 signalling-deficient mice. J Antimicrob Chemother. 2018 Aug 1;73(8):2089-2094.
CAS Number
– 2089321-00-4
Molecular Weight
– 756.72
SMILES
– O=S(O)(C1=CC=C(C=C1)C)=O.FC(F)(C2=CC=C(C=N2)C#CC3=CC=C(C=C3)OCC4=CC=C(C=C4)C#N)[C@@](O)(C5=C(C=C(C=C5)F)F)CN6C=NN=N6
Clinical Information
– Phase 1
Research Area
– Infection
Solubility
– DMSO : 150 mg/mL (ultrasonic)
Target
– Cytochrome P450
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
