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Vofopitant (dihydrochloride)
$350 – $2,250
Products Details
Product Description
– Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [3H]SP binding to the NK1 receptor with pKi values of 9.5 and 10.6 in rat and human membranes respectively, acts as a potential broad-spectrum anti-emetic agent[1].
Web ID
– HY-12143
Storage Temperature
– 4°C (Powder, stored under nitrogen)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C21H25Cl2F3N6O
References
– [1]Gardner CJ, et al. GR205171: a novel antagonist with high affinity for the tachykinin NK1 receptor, and potent broad-spectrum anti-emetic activity. Regul Pept. 1996 Aug 27;65(1):45-53.
CAS Number
– 168266-51-1
Molecular Weight
– 505.36
Compound Purity
– 99.11
SMILES
– COC1=C(CN[C@H]2CCCN[C@H]2C3=CC=CC=C3)C=C(N4N=NN=C4C(F)(F)F)C=C1.[H]Cl.[H]Cl
Clinical Information
– Phase 2
Research Area
– Cancer; Neurological Disease; Endocrinology
Solubility
– DMSO : 33.33 mg/mL (ultrasonic)|H2O : 33.33 mg/mL (ultrasonic)
Target
– Neurokinin Receptor
Isoform
– NK1
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
