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Product Description
– VO-OHPic is a reversible, noncompetitive and selective PTEN inhibitor with an IC50 of 46 nM. VO-OHPic attenuates apoptosis, adverse cardiac remodeling, and pro-inflammatory M1 macrophages in doxorubicin-induced cardiomyopathy. VO-OHPic inhibits autophagy[1][2][3].
Web ID
– HY-110067
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C12H10N2O8V
Citations
– Phytomedicine. 2023 Sep 22, 155117.|SSRN. 2023 Jul 17.|Biochem Pharmacol. 2020 Jan;171:113715.|Biochem Pharmacol. 2019 Oct;168:82-90. |Biochim Biophys Acta Mol Basis Dis. 25 October 2021, 166292.|BMC Cancer. 2019 Apr 25;19(1):391.|Bone Res. 2018 Nov 10;6:32.|Cancer Med. 2019 Aug;8(9):4265-4277.|Cell Death Dis. 2019 May; 10(5): 329.|Cell Stem Cell. 2022 Apr 7;29(4):545-558.e13.|Clin Transl Med. 2020 Dec;10(8):e240.|Clin Transl Med. 2022 Sep;12(9):e1061.|Environ Sci Technol. 2020 Sep 1;54(17):10783-10796.|Eur Rev Med Pharmacol Sci. 2019 May;23(10):4406-4413.|Int Immunopharmacol. 2021 Dec 23;103:107840.|Int J Mol Med. 2021 Apr 19.|Int J Mol Sci. 2023 Jun 9, 24(12), 9954.|J Cell Mol Med. 2019 Nov;23(11):7535-7544.|Mol Med Rep. 2018 Dec;18(6):5489-5501.|Mol Med Rep. 2022 Jul;26(1):246.|Mol Nutr Food Res. 2019 Dec;63(24):e1900418.|Mol Vis. 2018 Jul 23;24:485-494.|Redox Biol. 2019 Jan;20:390-401. |Stem Cell Res Ther. 2019 Jul 29;10(1):217.|Theranostics. 2019 Jul 9;9(16):4764-4778.|Theranostics. 2019 Jul 9;9(18):5200-5213.|Transl Psychiatry. 2021 Mar 26;11(1):185.
References
– [1]Wang W, et al. PTEN inhibitor VO-OHpic suppresses TSC2-/- MEFs proliferation by excessively inhibiting autophagy via the PTEN/PRAS40 pathway. Exp Ther Med. 2020 Jun;19(6):3565-3570. |[2]Mak LH, et al. Characterisation of the PTEN inhibitor VO-OHpic. J Chem Biol. 2010 Oct;3(4):157-63. doi: 10.1007/s12154-010-0041-7. Epub 2010 Jun 4.|[3]Johnson TA, et al. PTEN inhibitor VO-OHpic attenuates inflammatory M1 macrophages and cardiac remodeling in doxorubicin-induced cardiomyopathy. Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1236-H1249.
CAS Number
– 675848-25-6
Molecular Weight
– 361.16
SMILES
– [OH2][V+2]([N]1=CC=CC(O)=C1C2=O)([O-]2)([O-]C3=CC=CN=C3C4=O)([O-]4)=O.[H+]
Clinical Information
– No Development Reported
Research Area
– Cancer; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Autophagy;PTEN
Pathway
– Apoptosis;Autophagy;PI3K/Akt/mTOR
Product type
– Reference compound
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