VLX600

$61$1,210

Products Details

Product Description

– VLX600 is an iron-chelating inhibitor of oxidative phosphorylation (OXPHOS). VLX600 causes mitochondrial dysfunction and induces a strong shift to glycolysis. VLX600 displays selective cytotoxic activity against malignant cell and induces autophagy. Anticancer activity[1][2].

Web ID

– HY-12406

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Cancer-Kinase/protease

Molecular Formula

– C17H15N7

References

– [1]Karlsson H, et al. A novel tumor spheroid model identifies selective enhancement of radiation by an inhibitor of oxidative phosphorylation. Oncotarget. 2019 Sep 3;10(51):5372-5382.|[2]Zhang X, et al. Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments. Nat Commun. 2014;5:3295.

CAS Number

– 327031-55-0

Molecular Weight

– 317.35

Compound Purity

– 98.17

SMILES

– CC1=C(NC2=C3N=NC(N/N=C(C4=CC=CC=N4)C)=N2)C3=CC=C1

Clinical Information

– Phase 1

Research Area

– Cancer

Solubility

– DMSO : 25 mg/mL (ultrasonic)

Target

– Autophagy;Mitochondrial Metabolism

Pathway

– Autophagy;Metabolic Enzyme/Protease

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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