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Verapamil
$85 – $94
Products Details
Product Description
– Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart arrhythmias and angina research[1][2][3].
Web ID
– HY-14275
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C27H38N2O4
Citations
– Adv Mater. 2023 Sep 27:e2211980.|Antibiotics (Basel). 2022 Jul 26;11(8):1005.|Bioact Mater. 2021 Apr 21;6(11):4073-4082.|Biochem Biophys Res Commun. 2023 Nov 24, 149314.|Biomed Pharmacother. 2020 Sep;129:110506.|Biomed Res Int. 2021 May 15.|Br J Pharmacol. 2021 Jul 3.|Eur J Pharmacol. 2021 Oct 7;174552.|Eur J Pharmacol. 2022 Oct 25;175343.|J Med Chem. 2021 Mar 11;64(5):2725-2738.|Microbiol Spectr. 2023 Dec 4:e0251023.|Neurochem Res. 2022 Dec 8.|Pak J Pharm Sci. 2022 Mar;35(2):571-578.|Pak J Pharm Sci. 2022 Mar;35(2):587-594.|Pestic Biochem Physiol. August 2022, 105170.|Pharmacol Res Perspect. 2022 Feb;10(1):e00928.|Research Square Preprint. 2020 Dec.|Research Square Preprint. 2020 Oct.|Research Square Print. 2022.|SSRN. 8 Nov 2022|Biochem Biophys Res Commun. 2020 Jan 15;521(3):596-602.|Cancer Cell Int. 2021 Feb 16;21(1):108.|Cancer Cell. 2017 Apr 10;31(4):501-515.e8. |Cancer Sci. 2018 Apr;109(4):1135-1146. |Cell Calcium. 2020 May;87:102171.|Cell Stem Cell. 2023 Apr 6;30(4):378-395.e8.|Faculty of Pharmacy in Hradec Králové. Department of Pharmacology and Toxicology. Charles University 2019 Apr.|Food Funct. 2021 Aug 10.|Inflammopharmacology. 2023 Mar 28.|J Pharm Anal. 2020 Apr;10(2):178-186.|Mol Cell Endocrinol. 2019 Aug 20;494:110490. |Pharm Biol. 2019 Dec;57(1):477-484.|Phytomedicine. 2019 Mar 15;56:175-182. |Toxicol Appl Pharmacol. 2019 Apr 1;368:18-25.|Toxicology Research and Application. September 25, 2018.|Toxicology Research and Application. 2018, 2:239784731880115. |Xenobiotica. 2019 Dec;49(12):1485-1493.
References
– [1]Zhou P, et al. Anti-arrhythmic effect of Verapamil is accompanied by preservation of cx43 protein in rat heart. PLoS One. 2013 Aug 12;8(8):e71567.|[2]Gowarty JL, et al. Verapamil as a culprit of palbociclib toxicity. J Oncol Pharm Pract. 2019 Apr;25(3):743-746.|[3]Krikler DM. Verapamil in arrhythmia. Br J Clin Pharmacol. 1986;21 Suppl 2:183S-189S.|[4]Rehnqvist N,et al. Effects of metoprolol vs verapamil in patients with stable angina pectoris. The Angina Prognosis Study in Stockholm (APSIS). Eur Heart J. 1996 Jan;17(1):76-81.|[5]Kubo Y, et al. Blood-to-Retina Transport of Fluorescence-Labeled Verapamil at the Blood-Retinal Barrier. Pharm Res. 2018 Mar 12;35(5):93.
CAS Number
– 52-53-9
Molecular Weight
– 454.60
Compound Purity
– 99.96
SMILES
– COC1=CC=C(C(C#N)(C(C)C)CCCN(CCC2=CC=C(OC)C(OC)=C2)C)C=C1OC
Clinical Information
– Launched
Research Area
– Metabolic Disease; Cancer
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Calcium Channel;Cytochrome P450;P-glycoprotein
Isoform
– CYP3
Pathway
– Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
