Products Details

Product Description

– Vem-L-Cy5 (compound 3),modified with the NIR fluorophore cyanine-5 (Cy5),is a Vemurafenib (HY-12057)-based inhibitor of BRAF. Vem-L-Cy5 targets to BRAFV600E,and also inhibits MEK phosphorylation. Vem-L-Cy5 has cell permeability,and inhibits cell growth of many types of cancer[1].

Web ID

– HY-149380

Shipping

– Room temperature

Molecular Formula

– C63H68F5N7O9S

References

– [1]Barresi E, et al. A cyanine-based NIR fluorescent Vemurafenib analog to probe BRAFV600E in cancer cells. Eur J Med Chem. 2023 Aug 5;256:115446.

Molecular Weight

– 1194.31

SMILES

– CC1(C)C(/C=C/C=C/C=C2N(CCCCCC(NCCOCCOCC(NC3=CC=C(C4=CN=C(NC=C5C(C6=C(F)C=CC(NS(=O)(CCC)=O)=C6F)=O)C5=C4)C=C3)=O)=O)C7=C(C=CC=C7)C/2(C)C)=[N+](C)C8=C1C=CC=C8.O=C([O-])C(F)(F)F

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– Raf

Pathway

– MAPK/ERK Pathway

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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